❖ CASE 2

A 40-year-old woman presents for evaluation of her chronic migraine

headaches. She reports that approximately once a month she has a severe, unilateral

headache associated with nausea and extreme photophobia. The

headache will last for a full day if not treated. She has had success in reducing

the severity of the headaches with opioid pain medications, but usually she is

too nauseous to take them. When she is able to tolerate them, she will have to

sleep for several hours afterwards. She is missing about a day of work a month

because of the headaches. She has no other significant medical history and

takes no medications on a regular basis. Her examination today is normal. You

decide to prescribe sumatriptan for her to try with her next migraine headache.

◆ Which receptor is the site of action of sumatriptan?
◆ What is the mechanism of action of sumatriptan?

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referance : Case Files™ Pharmacology